Repeated Randomization and Matching in Multi-Arm Trials
نویسندگان
چکیده
منابع مشابه
Randomization , Rerandomization and Matching in Clinical Trials
Randomization was a key contribution of Sir Ronald Fisher to the conduct of scientific investigations. Along with the protective aspects of randomization, Fisher also noted that the distribution induced by randomization can form the basis of inference. Indeed, in some instances, the randomization test and related procedures seem to be the only tools available for inference. Several authors have...
متن کاملA comparison of bayesian adaptive randomization and multi-stage designs for multi-arm clinical trials
When several experimental treatments are available for testing, multi-arm trials provide gains in efficiency over separate trials. Including interim analyses allows the investigator to effectively use the data gathered during the trial. Bayesian adaptive randomization (AR) and multi-arm multi-stage (MAMS) designs are two distinct methods that use patient outcomes to improve the efficiency and e...
متن کاملA simulation study of outcome adaptive randomization in multi-arm clinical trials.
Randomizing patients among treatments with equal probabilities in clinical trials is the established method to obtain unbiased comparisons. In recent years, motivated by ethical considerations, many authors have proposed outcome adaptive randomization, wherein the randomization probabilities are unbalanced, based on interim data, to favor treatment arms having more favorable outcomes. While the...
متن کاملTreatment selection in multi-arm, multi-stage clinical trials
Adaptive designs that are based on group-sequential approaches have the benefit of being efficient as stopping boundaries can be found that lead to good operating characteristics with test decisions based solely on sufficient statistics. The drawback of these so called “pre-planned adaptive” designs is that unexpected design changes are not possible without impacting the error rates. “Flexible ...
متن کاملOptimal design for multi-arm multi-stage clinical trials
In early stages of drug development there is often uncertainty about the most promising among a set of different treatments. In order to ensure the best use of resources it is important to decide which, if any, of the treatments should be taken forward for further testing. Multi-arm multi-stage (MAMS) trials provide gains in efficiency over separate randomised trials of each treatment. They all...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Biometrics
سال: 2013
ISSN: 0006-341X
DOI: 10.1111/biom.12077